A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis
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چکیده
منابع مشابه
A proposal for an individualized pharmacogenetic-guided isoniazid dosage regimen for patients with tuberculosis
BACKGROUND/AIM Isoniazid (INH) is an essential component of first-line anti-tuberculosis (TB) treatment. However, treatment with INH is complicated by polymorphisms in the expression of the enzyme system primarily responsible for its elimination, N-acetyltransferase 2 (NAT2), and its associated hepatotoxicity. The objective of this study was to develop an individualized INH dosing regimen using...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2015
ISSN: 1177-8881
DOI: 10.2147/dddt.s87131